Cranial ultrasound characteristics and new reference values of cerebral parameters in hospitalized neonates

Title : Cranial ultrasound characteristics and new reference values of cerebral parameters in hospitalized neonates

Abstract:

Background: We aim to investigate the incidence and perinatal risk factors of cranial ultrasound(CUS) abnormalities in hospitalized neonates,build new reference values of cerebral parameters in newborns.
Methods: All CUS data of newborns hospitalized in the First Affiliated Hospital of Xi'an Jiaotong University from January 2021 to June 2024 were collected. Univariate analysis and multinomial logistic regression were used to evaluate the influence of different variables on cranial performance.
Results: Abnormal CUS images were found in 728/1728 hospitalized infants(42%),which mainly included intraventricular hemorrhage(25%),periventricular white matter echogenicity(11.4%) and choroid plexus cyst(4.2%).Small gestational age, in vitro fertilization and embryo transfer, Apgar ?7, congenital heart disease , neonatal respiratory distress syndrome and hypothyroidism of mother were related to abnormal cranial performance. 1000 normal cranial data were used to plot the reference range curves of frontal lobe thickness,transverse cerebral diameter and hemodynamics parameters of 24-42 weeks gestation.With the increase of gestational age, frontal lobe thickness, transverse cerebral diameter increased significantly and hemodynamics parameters tended to level off.
Conclusion: We recommend the new reference criteria for brain volume parameters and hemodynamics for hospitalized newborns.CUS monitor in early stage is critical for infants with high-risk factors,which promotes the timely detection of abnormalities and the reduction of neonatal mortality.

Biography:

Professor Liu is a neonatologist, doctoral degree tutor, the founder and discipline leader of Department of Neonatology，the First Affiliated Hospital of Xi 'an Jiaotong University, visiting scientist at Medical school of Harvard University. She obtained her doctoral degree from Xi'an Jiaotong University in 2009. Her research focuses on the brain development and injury, especially in premature infants.She has previously led four projects funded by the National Natural Science Foundation of China and published more than 50 research articles in SCI(E) journals. And She was awarded the "China Neonatal Physician Award"、"National Science and Technology Award". She is Vice President of Neonatal Branch of Chinese Medical Doctor Association, deputy chairman of the special Committee on Child health and chairman of the Professional Committee on early Childhood Health Development, Head of the neonatal Cooperation Group in Northwest China and chairman of the Expert Committee, Chairman of neonatologists Branch of Shaanxi Provincial Medical Association. And she is also a member of the editorial boards of more than ten domestic and internationl magazines.